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DNA was extracted from blood samples collected at various time intervals between birth and death, and methylation levels were measured using the Illumina Infinium HumanMethylation450 or MethylationEPIC BeadChip arrays

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In addition to increasing the risk of cancer and cardiovascular and pulmonary diseases, smoking promotes a pro-inflammatory metabolic state

He said the research explains variations found in data collected in numerous other studies conducted over decades