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Limitations of the study One can argue that we have not tested the effects on the sinus node of man directly, but only in mice

These antidiabetic agents increase the glucose-dependent secretion of insulin from functioning beta cells, decrease glucagon release after meals, decrease hepatic glucose production, delayed gastric emptying, suppress the appetite and promotes beta cell proliferation

Vildagliptin, a dpp-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin