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Nicotine activates, saturates and desensitizes dopamine pathway receptors, which is followed by growth or activation of millions of extra receptors, a process known as up-regulation

It also means that people who do not smoke or would not have otherwise smoked should not use e-cigarettes. A Serious Lack of Long-term Health Studies One of the main concerns regarding the use of e-cigarettes as a smoking cessation tool is the dearth of studies on their long-term effects