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Interestingly, miRNAs like miR-9-5p exhibit dual roles: acting as an oncomiR in HPV16 + SCC cell lines (CaSki, SiHa) by repressing TWIST1 and CDH1, thus promoting epithelialmesenchymal transition (EMT), but displaying a tumor-suppressive profile in HPV18 + adenocarcinoma cells (HeLa) due to differential regulation of CDH2 ( Other oncogenic miRNAs, such as miR-499, enhance tumor aggressiveness by downregulating SOX6 (Wang et al., 2017

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Filtered cigarettes contain filters that trap some of the harmful chemicals found in regular cigarettes before they reach your lungs and mouth