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As the AHA points out, The data on health effects to date, studied primarily in healthy people with short-term exposure, reveal little or no evidence of severe adverse events

summarized in "Tough New Tobacco Products Control Legislation Comes into Effect"

On average, smokers who dont quit lose around a decade of life

Nevertheless, a significant number of biomarker-based studies, cell/ in vitro and animal studies did indicate that e-cigarette exposure can result in oxidative stress, cellular apoptosis, DNA damage, genotoxicity, and tumor growth (Figure 2, and Supplementary file Materials 2 and 3), all of which can potentially increase risk of developing lung cancer or progression of any cancer